Aldometanib, CAS [[2904601-67-6]]

Produktübersicht

• Artikelname: Aldometanib, CAS [[2904601-67-6]]
• Artikelnummer: FBM-10-4445
• Hersteller Artikelnummer: 10-4445
• Alternativnummer: FBM-10-4445-5MG, FBM-10-4445-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 1-[(2,6-Dichlorophenyl)methyl]-3-hexadecyl-2-methylimidazol-1-ium iodide. Alternate Names: LXY-05-029

Produktbeschreibung

Aldolase inhibitor

Produkteigenschaften

• Molekulargewicht: 593.46
• Reinheit: >98% by TLC NMR (Conforms)
• Formulierung: White to off-white solid
• CAS Nummer: [2904601-67-6]
• Formel: C27H43Cl2IN2

Anwendungsbeschreibung

• Anwendungsbeschreibung: Aldometanib inhibits (IC50 = 50 µM) aldolase by blocking its binding with fructose-1,6-bisphosphate (FBP).1 It activates lysosomal AMPK and mimics a cellular state of glucose starvation. Aldometanib alleviated fatty liver and nonalcoholic steatohepatitis in mice and extended lifespan. It mitigated inflammation and oxidative stress damage in LPS-treated lung fibroblasts and also inhibited NLRP3-mediated pyroptosis.2 Aldometanib inhibited hepatocellular carcinoma in mice in an AMPK-dependent manner.3 It rebalanced the tumor microenvironment allowing cytotoxic CD8+ T cells to infiltrate tumor cells.