Aldometanib, CAS [[2904601-67-6]]

Product Overview

• Article Name: Aldometanib, CAS [[2904601-67-6]]
• Biozol Catalog Number: FBM-10-4445
• Supplier Catalog Number: 10-4445
• Alternative Catalog Number: FBM-10-4445-5MG, FBM-10-4445-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 1-[(2,6-Dichlorophenyl)methyl]-3-hexadecyl-2-methylimidazol-1-ium iodide. Alternate Names: LXY-05-029

Product Description

Aldolase inhibitor

Product Properties

• Molecular Weight: 593.46
• Purity: >98% by TLC NMR (Conforms)
• Form: White to off-white solid
• CAS Number: [2904601-67-6]
• Formula: C27H43Cl2IN2

Application Notes

• Application Notes: Aldometanib inhibits (IC50 = 50 µM) aldolase by blocking its binding with fructose-1,6-bisphosphate (FBP).1 It activates lysosomal AMPK and mimics a cellular state of glucose starvation. Aldometanib alleviated fatty liver and nonalcoholic steatohepatitis in mice and extended lifespan. It mitigated inflammation and oxidative stress damage in LPS-treated lung fibroblasts and also inhibited NLRP3-mediated pyroptosis.2 Aldometanib inhibited hepatocellular carcinoma in mice in an AMPK-dependent manner.3 It rebalanced the tumor microenvironment allowing cytotoxic CD8+ T cells to infiltrate tumor cells.