Linrodostat, CAS [[1923833-60-6]]

Produktübersicht

• Artikelname: Linrodostat, CAS [[1923833-60-6]]
• Artikelnummer: FBM-10-4473
• Hersteller Artikelnummer: 10-4473
• Alternativnummer: FBM-10-4473-5MG, FBM-10-4473-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (2R)-N-(4-Chlorophenyl)-2-[4-(6-fluoroquinolin-4-yl)cyclohexyl]propenamide. Alternate Names: BMS-986205

Produktbeschreibung

IDO1 inhibitor

Produkteigenschaften

• Molekulargewicht: 410.92
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [1923833-60-6]
• Formel: C24H24ClFN2O

Anwendungsbeschreibung

• Anwendungsbeschreibung: Linrodostat is an irreversible inhibitor (IC50 = 1.1 nM HEK293 cells, 1.7 nM HeLa cells) of indoleamine 2,3-dioxygenase 1 (IDO1), an enzyme that metabolizes tryptophan into immunosuppressive kynurenine.1,2,3 Acts synergistically with PD-1 inhibitors in various cancer models including bladder4, advanced solid tumors5, and hematologic5.