Linrodostat, CAS [[1923833-60-6]]

Product Overview

• Article Name: Linrodostat, CAS [[1923833-60-6]]
• Biozol Catalog Number: FBM-10-4473
• Supplier Catalog Number: 10-4473
• Alternative Catalog Number: FBM-10-4473-5MG, FBM-10-4473-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (2R)-N-(4-Chlorophenyl)-2-[4-(6-fluoroquinolin-4-yl)cyclohexyl]propenamide. Alternate Names: BMS-986205

Product Description

IDO1 inhibitor

Product Properties

• Molecular Weight: 410.92
• Purity: >98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [1923833-60-6]
• Formula: C24H24ClFN2O

Application Notes

• Application Notes: Linrodostat is an irreversible inhibitor (IC50 = 1.1 nM HEK293 cells, 1.7 nM HeLa cells) of indoleamine 2,3-dioxygenase 1 (IDO1), an enzyme that metabolizes tryptophan into immunosuppressive kynurenine.1,2,3 Acts synergistically with PD-1 inhibitors in various cancer models including bladder4, advanced solid tumors5, and hematologic5.