Chemical Name: N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4(dimethylamino)-2E-butenamide. Alternate Names: BIBW2992
EGFR and HER2 inhibitor
Molekulargewicht:
485.94
Reinheit:
99% by HPLC, NMR (Conforms)
Formulierung:
Pale yellow solid
CAS Nummer:
[850140-72-6]
Formel:
C24H25ClFN5O3
Anwendungsbeschreibung:
Afatinib is a clinically useful kinase inhibitor approved for the treatment of non-small cell lung cancer. It is a potent and highly selective inhibitor of mutant and wild-type EGFR (IC50 = 0.5 nM) and HER2 (IC50 = 14 nM).
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