Ruxolitinib, CAS [[941678-49-5]]

Produktübersicht

• Artikelname: Ruxolitinib, CAS [[941678-49-5]]
• Artikelnummer: FBM-10-4511
• Hersteller Artikelnummer: 10-4511
• Alternativnummer: FBM-10-4511-5MG, FBM-10-4511-25MG, FBM-10-4511-10MM/1MLDMSO
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: betaR-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile. Alternate Names: INCB 018424

Produktbeschreibung

JAK inhibitor

Produkteigenschaften

• Molekulargewicht: 306.37
• Reinheit: 99% by HPLC, NMR (conforms)
• Formulierung: White solid
• CAS Nummer: [941678-49-5]
• Formel: C17H18N6

Anwendungsbeschreibung

• Anwendungsbeschreibung: Potent and selective JAK1&2 inhibitor, IC50s=2.7, 4.5 and 322 nM forJAK1, JAK2 and JAK3 respectively.1 Blocks IL-6 signaling (IC50=281 nM) and proliferation of JAK2V617F+ Ba/F3 cells (IC50=127 nM).2 Inhibits the proinflammatory secretome of senescent cells.3 The JAK1 S646P mutant is highly sensitive to ruxolitinib.4 Clinically useful cancer chemotherapeutic.