Chemical Name: betaR-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile. Alternate Names: INCB 018424
JAK inhibitor
Molecular Weight:
306.37
Purity:
99% by HPLC, NMR (conforms)
Form:
White solid
CAS Number:
[941678-49-5]
Formula:
C17H18N6
Application Notes:
Potent and selective JAK1&2 inhibitor, IC50s=2.7, 4.5 and 322 nM forJAK1, JAK2 and JAK3 respectively.1 Blocks IL-6 signaling (IC50=281 nM) and proliferation of JAK2V617F+ Ba/F3 cells (IC50=127 nM).2 Inhibits the proinflammatory secretome of senescent cells.3 The JAK1 S646P mutant is highly sensitive to ruxolitinib.4 Clinically useful cancer chemotherapeutic.
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