Chemical Name: 1-(4-Ethoxycarbonylphenyl-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone
GPR40 antagonist
Molekulargewicht:
520.59
Reinheit:
96% by LCMS NMR (Conforms)
Formulierung:
White solid
CAS Nummer:
[306974-70-9]
Formel:
C27H25FN4O4S
Anwendungsbeschreibung:
Selective antagonist of GPR40. GW1100 inhibits GRP40-mediated Ca2+ increases stimulated GW9508 or linoleic acid (pIC50 = 5.99 for either agonist).1 The effects of GPR40 activation on insulin secretion in cells are also blocked by the addition of GW1100. GW1100 does not influence calcium mobilization mediated by GPR120.
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