Tubastatin A HCl, CAS [[1310693-92-5]]

Produktübersicht

• Artikelname: Tubastatin A HCl, CAS [[1310693-92-5]]
• Artikelnummer: FBM-10-4530
• Hersteller Artikelnummer: 10-4530
• Alternativnummer: FBM-10-4530-5MG, FBM-10-4530-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N-Hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride

Produktbeschreibung

HDAC-6 inhibitor

Produkteigenschaften

• Molekulargewicht: 371.86
• Reinheit: 99% by HPLC, NMR (Conforms)
• Formulierung: solid
• CAS Nummer: [1310693-92-5]
• Formel: C20H22N3O2 HCl

Anwendungsbeschreibung

• Anwendungsbeschreibung: Tubastatin A is a potent and highly selective inhibitor of HDAC6 (IC50 = 15 nM, >1000-fold selectivity against other HDAC isoforms, approx. 60-fold versus HDAC8).1 It displayed anti-inflammatory and anti-rheumatic effects in Freunds competitive adjuvant induced animal model of inflammation.2 Tubastatin A inhibited TNF-alpha (IC50 = 272 nM) and IL-6 (IC50 = 712 nM) in LPS stimulated human THP-1 macrophages.2 Tubastatin A has also been shown to have therapeutic potential for treatment of Alzheimers disease via altered amloid-beta load and reduced tau hyperphosphorylation.3,4,5