Chemical Name: N-Hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride
HDAC-6 inhibitor
Molecular Weight:
371.86
Purity:
99% by HPLC, NMR (Conforms)
Form:
solid
CAS Number:
[1310693-92-5]
Formula:
C20H22N3O2 HCl
Application Notes:
Tubastatin A is a potent and highly selective inhibitor of HDAC6 (IC50 = 15 nM, >1000-fold selectivity against other HDAC isoforms, approx. 60-fold versus HDAC8).1 It displayed anti-inflammatory and anti-rheumatic effects in Freunds competitive adjuvant induced animal model of inflammation.2 Tubastatin A inhibited TNF-alpha (IC50 = 272 nM) and IL-6 (IC50 = 712 nM) in LPS stimulated human THP-1 macrophages.2 Tubastatin A has also been shown to have therapeutic potential for treatment of Alzheimers disease via altered amloid-beta load and reduced tau hyperphosphorylation.3,4,5
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