POB, CAS [[946135-39-3]]

Produktübersicht

• Artikelname: POB, CAS [[946135-39-3]]
• Artikelnummer: FBM-10-4553
• Hersteller Artikelnummer: 10-4553
• Alternativnummer: FBM-10-4553-10MG, FBM-10-4553-50MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N-(4-Pyridoxyl)-L-Ornithine(BOC)-Ome

Produktbeschreibung

Ornithine decarboxylase inhibitor

Produkteigenschaften

• Molekulargewicht: 397.47
• Reinheit: 98% by HPLC, NMR (Confirms)
• Formulierung: White solid
• CAS Nummer: [946135-39-3]
• Formel: C19H31N3O6

Anwendungsbeschreibung

• Anwendungsbeschreibung: Pyridoxal 5-phosphate - dependent ornithine decarboxylase (ODC) is a key enzyme involved in polyamine synthesis and a potential cancer drug target. POB is a transition state-based, cell permeable pro-drug inhibitor of ODC. Intracellularly, POB is phosphorylated by pyridoxal kinase and the methyl ester hydrolyzed. This active inhibitor most likely binds apo-ODC resulting in greatly reduced ODC activity and inhibition of cellular proliferation. POB was able to inhibit proliferation in a wide variety of tumor cell lines: LN229 (IC50 = 50 µM), Jurkat, COS7, SW2 and both high and low-grade glioblastoma multiforme. More potent than DFMO.