Chemical Name: N-(4-Pyridoxyl)-L-Ornithine(BOC)-Ome
Ornithine decarboxylase inhibitor
Molecular Weight:
397.47
Purity:
98% by HPLC, NMR (Confirms)
Form:
White solid
CAS Number:
[946135-39-3]
Formula:
C19H31N3O6
Application Notes:
Pyridoxal 5-phosphate - dependent ornithine decarboxylase (ODC) is a key enzyme involved in polyamine synthesis and a potential cancer drug target. POB is a transition state-based, cell permeable pro-drug inhibitor of ODC. Intracellularly, POB is phosphorylated by pyridoxal kinase and the methyl ester hydrolyzed. This active inhibitor most likely binds apo-ODC resulting in greatly reduced ODC activity and inhibition of cellular proliferation. POB was able to inhibit proliferation in a wide variety of tumor cell lines: LN229 (IC50 = 50 µM), Jurkat, COS7, SW2 and both high and low-grade glioblastoma multiforme. More potent than DFMO.
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