Chemical Name: 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-ylsulfonyl)-4-(4-methoxyphenylsulfonyl)piperazine. Alternate Names: ML083
PKM2 activator
Molekulargewicht:
454.51
Reinheit:
98% by TLC, NMR (Conforms)
Formulierung:
white solid
CAS Nummer:
[562867-96-3]
Formel:
C19H22N2O7S2
Anwendungsbeschreibung:
BML283 is a selective activator of the Tumor Specific M2 Isoform of Pyruvate Kinase (PKM2) - AC50 = 111nM.1 PKM2 activity is downregulated in most cancer cells leading to a decrease in catabolic metabolism and an increase in anabolic metabolism.2,3 BML283 is an important tool for studying the effects of PKM2 and cancer metabolism.
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