NLG919, CAS [[1402836-58-1]]

Produktübersicht

• Artikelname: NLG919, CAS [[1402836-58-1]]
• Artikelnummer: FBM-10-4564
• Hersteller Artikelnummer: 10-4564
• Alternativnummer: FBM-10-4564-5MG, FBM-10-4564-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol

Produktbeschreibung

IDO pathway inhibitor

Produkteigenschaften

• Molekulargewicht: 282.39
• Reinheit: 985 by TLC, NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [1402836-58-1]
• Formel: C18H22N2O

Anwendungsbeschreibung

• Anwendungsbeschreibung: NLG919 (1402836-58-1) is a potent IDO-pathway inhibitor (Ki = 7nM, EC50 = 75nM).1 It synergizes with chemo-radiation therapy to promote T cell dependent complement deposition in a murine model of glioblastoma.2 In combination with paclitaxel in a mouse B16-F10 melanoma model, NLG919 increased the percentage of CD3+, CD8+, and CD4+ T cells and secretion of IFN-gamma and interleukin-2 while decreasing the percentage of CD4+CD25+ regulatory T cells.3