NLG919, CAS [[1402836-58-1]]

Product Overview

• Article Name: NLG919, CAS [[1402836-58-1]]
• Biozol Catalog Number: FBM-10-4564
• Supplier Catalog Number: 10-4564
• Alternative Catalog Number: FBM-10-4564-5MG, FBM-10-4564-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol

Product Description

IDO pathway inhibitor

Product Properties

• Molecular Weight: 282.39
• Purity: 985 by TLC, NMR (Conforms)
• Form: White solid
• CAS Number: [1402836-58-1]
• Formula: C18H22N2O

Application Notes

• Application Notes: NLG919 (1402836-58-1) is a potent IDO-pathway inhibitor (Ki = 7nM, EC50 = 75nM).1 It synergizes with chemo-radiation therapy to promote T cell dependent complement deposition in a murine model of glioblastoma.2 In combination with paclitaxel in a mouse B16-F10 melanoma model, NLG919 increased the percentage of CD3+, CD8+, and CD4+ T cells and secretion of IFN-gamma and interleukin-2 while decreasing the percentage of CD4+CD25+ regulatory T cells.3