L-Buthionine Sulfoximine, CAS [[5072-26-4]]

Produktübersicht

• Artikelname: L-Buthionine Sulfoximine, CAS [[5072-26-4]]
• Artikelnummer: FBM-10-4572
• Hersteller Artikelnummer: 10-4572
• Alternativnummer: FBM-10-4572-100MG,FBM-10-4572-250MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

GCL inhibitor

Produkteigenschaften

• Molekulargewicht: 222.31
• Reinheit: >98%, NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [5072-26-4]
• Formel: C8H18N2O3S

Anwendungsbeschreibung

• Anwendungsbeschreibung: Buthionine sulfoximine is an irreversible inhibitor of gamma-glutamylcysteine ligase (GCL). GCL is the first enzyme of the cellular glutathione biosynthetic pathway. Dysregulation of glutathione homeostasis is involved in many diseases including cancer, diabetes, neurodegenerative disorders and HIV/AIDS.1 Most disease states involve decreased glutathione synthesis, however, in cancer, it is increased supporting cellular proliferation and protecting cancer cells. Pharmacological inhibition of GCL has been examined as a potential cancer treatment.2-4