L-Buthionine Sulfoximine, CAS [[5072-26-4]]

Product Overview

• Article Name: L-Buthionine Sulfoximine, CAS [[5072-26-4]]
• Biozol Catalog Number: FBM-10-4572
• Supplier Catalog Number: 10-4572
• Alternative Catalog Number: FBM-10-4572-100MG, FBM-10-4572-250MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 2(S)-Amino-4-(S-butylsulfonimidoyl)butanoic acid

Product Description

GCL inhibitor

Product Properties

• Molecular Weight: 222.31
• Purity: >98%, NMR (Conforms)
• Form: White solid
• CAS Number: [5072-26-4]
• Formula: C8H18N2O3S

Application Notes

• Application Notes: Buthionine sulfoximine is an irreversible inhibitor of gamma-glutamylcysteine ligase (GCL). GCL is the first enzyme of the cellular glutathione biosynthetic pathway. Dysregulation of glutathione homeostasis is involved in many diseases including cancer, diabetes, neurodegenerative disorders and HIV/AIDS.1 Most disease states involve decreased glutathione synthesis, however, in cancer, it is increased supporting cellular proliferation and protecting cancer cells. Pharmacological inhibition of GCL has been examined as a potential cancer treatment.2-4