Fumarate hydratase-IN-1, CAS [[1644060-37-6]]

Produktübersicht

• Artikelname: Fumarate hydratase-IN-1, CAS [[1644060-37-6]]
• Artikelnummer: FBM-10-4578
• Hersteller Artikelnummer: 10-4578
• Alternativnummer: FBM-10-4578-5MG, FBM-10-4578-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: Ethyl rel-(3S,3aR)-3-[2-(Methylamino)-2-oxoethyl]-2-oxo-1-[(4-phenylphenyl)methyl]-3,4,5,6-tetrahydroindole-3a-carboxylate

Produktbeschreibung

Fumarate hydratase inhibitor

Produkteigenschaften

• Molekulargewicht: 446.55
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [1644060-37-6]
• Formel: C27H30N2O4

Anwendungsbeschreibung

• Anwendungsbeschreibung: Fumarate hydratase-IN-1 is a pro-drug inhibitor of fumarate hydratase, an important enzyme in the tricarboxylic acid (TCA) cycle. This cell permeable compound is converted to the active carboxylic acid by intracellular esterases (Ki = 4.5 µM for free acid). The ethyl ester displayed cell-growth inhibitory activity against several cancer lines under nutrient (glucose) deprived conditions with an average IC50 = 2.2 µM.