Fumarate hydratase-IN-1, CAS [[1644060-37-6]]

Product Overview

• Article Name: Fumarate hydratase-IN-1, CAS [[1644060-37-6]]
• Biozol Catalog Number: FBM-10-4578
• Supplier Catalog Number: 10-4578
• Alternative Catalog Number: FBM-10-4578-5MG,FBM-10-4578-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

Fumarate hydratase inhibitor

Product Properties

• Molecular Weight: 446.55
• Purity: >98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [1644060-37-6]
• Formula: C27H30N2O4

Application Notes

• Application Notes: Fumarate hydratase-IN-1 is a pro-drug inhibitor of fumarate hydratase, an important enzyme in the tricarboxylic acid (TCA) cycle. This cell permeable compound is converted to the active carboxylic acid by intracellular esterases (Ki = 4.5 µM for free acid). The ethyl ester displayed cell-growth inhibitory activity against several cancer lines under nutrient (glucose) deprived conditions with an average IC50 = 2.2 µM.