Chemical Name: 3-[(2-Methyl-2-propen-1-yl)sulfanyl]-5H-[1,2,4]triazino[5,6-b]indole
Eukaryotic ribosome assembly inhibitor
Molekulargewicht:
256.33
Reinheit:
>98% by TLC, NMR (Conforms)
Formulierung:
Pale yellow solid
CAS Nummer:
[328023-11-6]
Formel:
C13H12N4S
Anwendungsbeschreibung:
Rbin-1 is potent (GI50 = 136 nM) and reversible inhibitor of eukaryotic ribosome assembly. The biochemical target of Rbin-1 is Midasin (Mdn1), an essential AAA+ protein. Blocking of Mdn1 by Rbin-1 inhibits the processing of pre-60S particles, important pre-ribosomal subunits produced in the nucleolus.
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