Clodronate 2Na, CAS [[88416-50-6]]

Produktübersicht

• Artikelname: Clodronate 2Na, CAS [[88416-50-6]]
• Artikelnummer: FBM-10-4631
• Hersteller Artikelnummer: 10-4631
• Alternativnummer: FBM-10-4631-10MG,FBM-10-4631-50MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

Induces osteoclast apoptosis

Produkteigenschaften

• Molekulargewicht: 360.92
• Reinheit: 98%, NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [88416-50-6]
• Formel: CH2Cl2O6P22Na4H2O

Anwendungsbeschreibung

• Anwendungsbeschreibung: Clodronate is a first generation non-nitrogenous bisphosphonate drug for the prevention and treatment of osteoporosis and skeletal fractures/hypercalcemia in patients with cancer. It strongly binds to hydroxyapatite and directly reduces osteoclast activity.1 Clodronate is metabolized in vitro to a cytotoxic ATP analog (AppCCl2p) which inhibits ADP/ATP translocase in the mitochondrial inner membrane leading to osteoclast apoptosis.2