Clodronate 2Na, CAS [[88416-50-6]]

Product Overview

• Article Name: Clodronate 2Na, CAS [[88416-50-6]]
• Biozol Catalog Number: FBM-10-4631
• Supplier Catalog Number: 10-4631
• Alternative Catalog Number: FBM-10-4631-10MG, FBM-10-4631-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: Dichloromethylenediphosphonic acid disodium tetrahydrate

Product Description

Induces osteoclast apoptosis

Product Properties

• Molecular Weight: 360.92
• Purity: 98%, NMR (Conforms)
• Form: White solid
• CAS Number: [88416-50-6]
• Formula: CH2Cl2O6P22Na4H2O

Application Notes

• Application Notes: Clodronate is a first generation non-nitrogenous bisphosphonate drug for the prevention and treatment of osteoporosis and skeletal fractures/hypercalcemia in patients with cancer. It strongly binds to hydroxyapatite and directly reduces osteoclast activity.1 Clodronate is metabolized in vitro to a cytotoxic ATP analog (AppCCl2p) which inhibits ADP/ATP translocase in the mitochondrial inner membrane leading to osteoclast apoptosis.2