Nitisinone, CAS [[104206-65-7]]

Produktübersicht

• Artikelname: Nitisinone, CAS [[104206-65-7]]
• Artikelnummer: FBM-10-4648
• Hersteller Artikelnummer: 10-4648
• Alternativnummer: FBM-10-4648-50MG,FBM-10-4648-250MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: NTBC

Produktbeschreibung

Tyrosine metabolism inhibitor

Produkteigenschaften

• Molekulargewicht: 329.23
• Reinheit: >98% by TLC (NMR Conforms)
• Formulierung: Beige solid
• CAS Nummer: [104206-65-7]
• Formel: C14H10F3NO5

Anwendungsbeschreibung

• Anwendungsbeschreibung: Inhibitor of 4-Hydroxyphenylpyruvate dioxygenase (HPPD, IC50 = 40 nM1 and 173 nM2) and is in clinical use for the treatment of hereditary tyrosinemia type 13. CD13+ cancer stem cells (CSCs) are dependent on aerobic metabolism of tyrosine - Nitisinone inhibition of tyrosine metabolism results in lowered availability of acetyl-CoA and fumarate for use in the citric acid cycle causing these CSCs to enter cell cycle, decreasing self-renewal, and making them more susceptible to chemotherapy.4 Nitisinone is a potential treatment option for cancers that rely on tyrosine metabolism.