Nitisinone, CAS [[104206-65-7]]

Product Overview

• Article Name: Nitisinone, CAS [[104206-65-7]]
• Biozol Catalog Number: FBM-10-4648
• Supplier Catalog Number: 10-4648
• Alternative Catalog Number: FBM-10-4648-50MG, FBM-10-4648-250MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 2-[2-Nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione. Alternate Names: NTBC

Product Description

Tyrosine metabolism inhibitor

Product Properties

• Molecular Weight: 329.23
• Purity: >98% by TLC (NMR Conforms)
• Form: Beige solid
• CAS Number: [104206-65-7]
• Formula: C14H10F3NO5

Application Notes

• Application Notes: Inhibitor of 4-Hydroxyphenylpyruvate dioxygenase (HPPD, IC50 = 40 nM1 and 173 nM2) and is in clinical use for the treatment of hereditary tyrosinemia type 13. CD13+ cancer stem cells (CSCs) are dependent on aerobic metabolism of tyrosine - Nitisinone inhibition of tyrosine metabolism results in lowered availability of acetyl-CoA and fumarate for use in the citric acid cycle causing these CSCs to enter cell cycle, decreasing self-renewal, and making them more susceptible to chemotherapy.4 Nitisinone is a potential treatment option for cancers that rely on tyrosine metabolism.