P505-15, CAS [[1370261-97-4]]

Produktübersicht

• Artikelname: P505-15, CAS [[1370261-97-4]]
• Artikelnummer: FBM-10-4650
• Hersteller Artikelnummer: 10-4650
• Alternativnummer: FBM-10-4650-5MG, FBM-10-4650-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[3-(triazol-2-yl)anilino]pyrimidine-5-carboxamide hydrochloride. Alternate Names: PRT062607, BIIB-057

Produktbeschreibung

Highly selective Syk inhibitor

Produkteigenschaften

• Molekulargewicht: 429.91
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [1370261-97-4]
• Formel: C19H23N9OHCl

Anwendungsbeschreibung

• Anwendungsbeschreibung: P505-15 is a highly selective and potent (IC50 = 1-2 nM) inhibitor of spleen tyrosine kinase (Syk).1 It potently inhibited B cell antigen receptor-mediated B cell signaling/activation and basophil degranulation. It displayed anti-inflammatory activity in rodent models of rheumatoid arthritis. P505-15 displayed efficacy in vitro and in vivo in non-Hodgkin lymphoma and chronic lymphocytic leukemia models.2,3 It protected against toxin-induced hepatic fibrosis, associated hepatocellular injury, and hepatocarcinogenesis.4 P505-15 was also found to inhibit PINK1 (IC50 = 0.5-3 µM) in HeLa cells and dopaminergic neurons.5