P505-15, CAS [[1370261-97-4]]

Product Overview

• Article Name: P505-15, CAS [[1370261-97-4]]
• Biozol Catalog Number: FBM-10-4650
• Supplier Catalog Number: 10-4650
• Alternative Catalog Number: FBM-10-4650-5MG, FBM-10-4650-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[3-(triazol-2-yl)anilino]pyrimidine-5-carboxamide hydrochloride. Alternate Names: PRT062607, BIIB-057

Product Description

Highly selective Syk inhibitor

Product Properties

• Molecular Weight: 429.91
• Purity: >98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [1370261-97-4]
• Formula: C19H23N9OHCl

Application Notes

• Application Notes: P505-15 is a highly selective and potent (IC50 = 1-2 nM) inhibitor of spleen tyrosine kinase (Syk).1 It potently inhibited B cell antigen receptor-mediated B cell signaling/activation and basophil degranulation. It displayed anti-inflammatory activity in rodent models of rheumatoid arthritis. P505-15 displayed efficacy in vitro and in vivo in non-Hodgkin lymphoma and chronic lymphocytic leukemia models.2,3 It protected against toxin-induced hepatic fibrosis, associated hepatocellular injury, and hepatocarcinogenesis.4 P505-15 was also found to inhibit PINK1 (IC50 = 0.5-3 µM) in HeLa cells and dopaminergic neurons.5