Enasidenib, CAS [[1446502-11-9]]

Produktübersicht

• Artikelname: Enasidenib, CAS [[1446502-11-9]]
• Artikelnummer: FBM-10-4660
• Hersteller Artikelnummer: 10-4660
• Alternativnummer: FBM-10-4660-5MG, FBM-10-4660-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 2-Methyl-1-[[4-[6(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]-2-propanol. Alternate Names: AG-221

Produktbeschreibung

IDH2 inhibitor

Produkteigenschaften

• Molekulargewicht: 473.38
• Reinheit: 98%, NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [1446502-11-9]
• Formel: C19H17F6N7O

Anwendungsbeschreibung

• Anwendungsbeschreibung: Enasidenib is a potent (IC50s = 100 nM IDH2R140Q homodimer, 30 nM IDH2R140Q/WT heterodimer and 10 nM IDH2R172K/WT heterodimer) and selective inhibitor of mutant isocitrate dehydrogenase 2 (IDH2).1 It suppressed the production of the oncometabolite (R)-2-Hydroxyglutarate (a competitive inhibitor of alphaKG-dependent dioxygenases which leads to epigenetic dysregulation) and induced cellular differentiation in primary human IDH2 mutation-positive acute myeloid leukemia cells.1,2 Recently approved for clinical use by the FDA.