Enasidenib, CAS [[1446502-11-9]]

Product Overview

• Article Name: Enasidenib, CAS [[1446502-11-9]]
• Biozol Catalog Number: FBM-10-4660
• Supplier Catalog Number: 10-4660
• Alternative Catalog Number: FBM-10-4660-5MG, FBM-10-4660-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 2-Methyl-1-[[4-[6(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]-2-propanol. Alternate Names: AG-221

Product Description

IDH2 inhibitor

Product Properties

• Molecular Weight: 473.38
• Purity: 98%, NMR (Conforms)
• Form: White solid
• CAS Number: [1446502-11-9]
• Formula: C19H17F6N7O

Application Notes

• Application Notes: Enasidenib is a potent (IC50s = 100 nM IDH2R140Q homodimer, 30 nM IDH2R140Q/WT heterodimer and 10 nM IDH2R172K/WT heterodimer) and selective inhibitor of mutant isocitrate dehydrogenase 2 (IDH2).1 It suppressed the production of the oncometabolite (R)-2-Hydroxyglutarate (a competitive inhibitor of alphaKG-dependent dioxygenases which leads to epigenetic dysregulation) and induced cellular differentiation in primary human IDH2 mutation-positive acute myeloid leukemia cells.1,2 Recently approved for clinical use by the FDA.