Lomitapide, CAS [[182431-12-5]]

Produktübersicht

• Artikelname: Lomitapide, CAS [[182431-12-5]]
• Artikelnummer: FBM-10-4664
• Hersteller Artikelnummer: 10-4664
• Alternativnummer: FBM-10-4664-5MG,FBM-10-4664-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: AEGR-733, BMS-201038

Produktbeschreibung

Microsomal triglyceride transfer protein inhibitor

Produkteigenschaften

• Molekulargewicht: 693.73
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [182431-12-5]
• Formel: C39H37F6N3O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: Lomitapide is a potent (IC50 = 8 nM) inhibitor of microsomal triglyceride transfer protein (MTP or MTTP) and is clinically useful in treating familial hypercholesterolemia.1,2 It has displayed anticancer activity acting through various pathways including autophagy-dependent cancer cell death via direct inhibition of the kinase activity of mTORC13, activation of AMPK/Beclin1-mediated autophagy4, Notch inhibition via targeting TACE and gamma-secretase5, blocking ZDHHC5-dependent palmitoylation on SSTR56, PFKFB3 inhibition7, and PARP14/DRP1-mediated mitophagy8.