Lomitapide, CAS [[182431-12-5]]

Product Overview

• Article Name: Lomitapide, CAS [[182431-12-5]]
• Biozol Catalog Number: FBM-10-4664
• Supplier Catalog Number: 10-4664
• Alternative Catalog Number: FBM-10-4664-5MG,FBM-10-4664-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: AEGR-733, BMS-201038

Product Description

Microsomal triglyceride transfer protein inhibitor

Product Properties

• Molecular Weight: 693.73
• Purity: >98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [182431-12-5]
• Formula: C39H37F6N3O2

Application Notes

• Application Notes: Lomitapide is a potent (IC50 = 8 nM) inhibitor of microsomal triglyceride transfer protein (MTP or MTTP) and is clinically useful in treating familial hypercholesterolemia.1,2 It has displayed anticancer activity acting through various pathways including autophagy-dependent cancer cell death via direct inhibition of the kinase activity of mTORC13, activation of AMPK/Beclin1-mediated autophagy4, Notch inhibition via targeting TACE and gamma-secretase5, blocking ZDHHC5-dependent palmitoylation on SSTR56, PFKFB3 inhibition7, and PARP14/DRP1-mediated mitophagy8.