BO-264, CAS [[2408648-20-2]]

Produktübersicht

• Artikelname: BO-264, CAS [[2408648-20-2]]
• Artikelnummer: FBM-10-4685
• Hersteller Artikelnummer: 10-4685
• Alternativnummer: FBM-10-4685-5MG, FBM-10-4685-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 3-(4-Methoxyphenyl)-N-(2-morpholin-4-ylpyrimidin-4-yl)-1,2-oxazol-5-amine

Produktbeschreibung

TACCS inhibitor

Produkteigenschaften

• Molekulargewicht: 353.38
• Reinheit: 99% by HPLC NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [2408648-20-2]
• Formel: C18H19N5O3

Anwendungsbeschreibung

• Anwendungsbeschreibung: BO-264 is a potent (IC50 = 188 nM) inhibitor of transforming acidic coiled-coil 3 (TACC3), an important protein involved in microtubule stability and centrosome integrity.1 TACC3 is frequently upregulated in a broad range of cancers. BO-264 displayed significant anticancer activity in greater than 90% of cell lines in the NCI-60 human cancer cell line panel. Active in vivo in mice injected with JIMT-1 and EMT6 breast cancer cells as well as mouse colon cancer xenografts HCT-116 and CT-26.