BO-264, CAS [[2408648-20-2]]

Product Overview

• Article Name: BO-264, CAS [[2408648-20-2]]
• Biozol Catalog Number: FBM-10-4685
• Supplier Catalog Number: 10-4685
• Alternative Catalog Number: FBM-10-4685-5MG, FBM-10-4685-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 3-(4-Methoxyphenyl)-N-(2-morpholin-4-ylpyrimidin-4-yl)-1,2-oxazol-5-amine

Product Description

TACCS inhibitor

Product Properties

• Molecular Weight: 353.38
• Purity: 99% by HPLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [2408648-20-2]
• Formula: C18H19N5O3

Application Notes

• Application Notes: BO-264 is a potent (IC50 = 188 nM) inhibitor of transforming acidic coiled-coil 3 (TACC3), an important protein involved in microtubule stability and centrosome integrity.1 TACC3 is frequently upregulated in a broad range of cancers. BO-264 displayed significant anticancer activity in greater than 90% of cell lines in the NCI-60 human cancer cell line panel. Active in vivo in mice injected with JIMT-1 and EMT6 breast cancer cells as well as mouse colon cancer xenografts HCT-116 and CT-26.