GSK2606414, CAS [[1337531-36-8]]

Produktübersicht

• Artikelname: GSK2606414, CAS [[1337531-36-8]]
• Artikelnummer: FBM-10-4716
• Hersteller Artikelnummer: 10-4716
• Alternativnummer: FBM-10-4716-5MG, FBM-10-4716-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 1-[5-(4-Amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-[3-(trifluoromethyl)phenyl]ethenone

Produktbeschreibung

PERK inhibitor

Produkteigenschaften

• Molekulargewicht: 451.44
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [1337531-36-8]
• Formel: C24H20F3N5O

Anwendungsbeschreibung

• Anwendungsbeschreibung: Potent (IC50 = 0.4 nM) and selective (against a panel of 294 kinases) inhibitor of protein kinase R-like endoplasmic reticulum kinase (PERK), an important effector of the unfolded protein response (UPR).1 It prevented neurodegeneration in a mouse model of frontotemporal dementia2 and rodent models of Parkinsons disease via modulation of the UPR3. GSK2606414 has been reported to be a potent inhibitor of RIPK1 (IC50 = 18 nM).4 It has also displayed neuroprotective effects in various models of stroke.5-7