GSK2606414, CAS [[1337531-36-8]]

Product Overview

• Article Name: GSK2606414, CAS [[1337531-36-8]]
• Biozol Catalog Number: FBM-10-4716
• Supplier Catalog Number: 10-4716
• Alternative Catalog Number: FBM-10-4716-5MG, FBM-10-4716-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 1-[5-(4-Amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-[3-(trifluoromethyl)phenyl]ethenone

Product Description

PERK inhibitor

Product Properties

• Molecular Weight: 451.44
• Purity: 98% by HPLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [1337531-36-8]
• Formula: C24H20F3N5O

Application Notes

• Application Notes: Potent (IC50 = 0.4 nM) and selective (against a panel of 294 kinases) inhibitor of protein kinase R-like endoplasmic reticulum kinase (PERK), an important effector of the unfolded protein response (UPR).1 It prevented neurodegeneration in a mouse model of frontotemporal dementia2 and rodent models of Parkinsons disease via modulation of the UPR3. GSK2606414 has been reported to be a potent inhibitor of RIPK1 (IC50 = 18 nM).4 It has also displayed neuroprotective effects in various models of stroke.5-7