CB-103, CAS [[218457-67-1]]

Produktübersicht

• Artikelname: CB-103, CAS [[218457-67-1]]
• Artikelnummer: FBM-10-4742
• Hersteller Artikelnummer: 10-4742
• Alternativnummer: FBM-10-4742-20MG,FBM-10-4742-100MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

Notch signaling pathway inhibitor

Produkteigenschaften

• Molekulargewicht: 242.32
• Reinheit: 98% by HPLC, NMR (Conforms)
• Formulierung: Off-white to pale orange solid
• CAS Nummer: [218457-67-1]
• Formel: C15H18N2O

Anwendungsbeschreibung

• Anwendungsbeschreibung: Orally active inhibitor of the Notch signaling activation complex (IC50s from 0.9 to 3.9 µM in various cell-based assays), the most downstream level of the Notch signaling pathway. It inhibited the growth of Notch-addicted human T cell acute lymphoblastic leukemia cells as well as other cell lines. CB-103 also inhibited the growth of human breast cancer and leukemia xenografts without the intestinal toxicity associated with gamma-secretase Notch inhibitors.