CB-103, CAS [[218457-67-1]]

Product Overview

• Article Name: CB-103, CAS [[218457-67-1]]
• Biozol Catalog Number: FBM-10-4742
• Supplier Catalog Number: 10-4742
• Alternative Catalog Number: FBM-10-4742-20MG,FBM-10-4742-100MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

Notch signaling pathway inhibitor

Product Properties

• Molecular Weight: 242.32
• Purity: 98% by HPLC, NMR (Conforms)
• Form: Off-white to pale orange solid
• CAS Number: [218457-67-1]
• Formula: C15H18N2O

Application Notes

• Application Notes: Orally active inhibitor of the Notch signaling activation complex (IC50s from 0.9 to 3.9 µM in various cell-based assays), the most downstream level of the Notch signaling pathway. It inhibited the growth of Notch-addicted human T cell acute lymphoblastic leukemia cells as well as other cell lines. CB-103 also inhibited the growth of human breast cancer and leukemia xenografts without the intestinal toxicity associated with gamma-secretase Notch inhibitors.