MU1700, CAS [[1360905-04-9]]

Produktübersicht

• Artikelname: MU1700, CAS [[1360905-04-9]]
• Artikelnummer: FBM-10-4746
• Hersteller Artikelnummer: 10-4746
• Alternativnummer: FBM-10-4746-5MG, FBM-10-4746-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 6-(4-(Piperazin-1-yl)phenyl)-3-(quinoline-4-yl)furo[3,2-b]pyridine dihydrochloride

Produktbeschreibung

Selective ALK1/2 inhibitor

Produkteigenschaften

• Molekulargewicht: 479.41
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: Orange solid
• CAS Nummer: [1360905-04-9]
• Formel: C26H22N4O2HCl

Anwendungsbeschreibung

• Anwendungsbeschreibung: MU1700 is a potent (IC50s = 13 nM ALK1, 6 nM ALK2) and highly selective (selective against 369 kinases with only ALK6 (41 nM) being inhibited) ALK1/2 inhibitor. Much higher kinome selectivity than the typically used ALK 1/2 inhibitor LDN-193189. MU1700 exhibits favorable pharmacokinetic and bioavailability profiles for in vivo use. It showed excellent CNS penetration with brain concentrations exceeding that in plasma.