MU1700, CAS [[1360905-04-9]]

Product Overview

• Article Name: MU1700, CAS [[1360905-04-9]]
• Biozol Catalog Number: FBM-10-4746
• Supplier Catalog Number: 10-4746
• Alternative Catalog Number: FBM-10-4746-5MG, FBM-10-4746-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 6-(4-(Piperazin-1-yl)phenyl)-3-(quinoline-4-yl)furo[3,2-b]pyridine dihydrochloride

Product Description

Selective ALK1/2 inhibitor

Product Properties

• Molecular Weight: 479.41
• Purity: >98% by HPLC NMR (Conforms)
• Form: Orange solid
• CAS Number: [1360905-04-9]
• Formula: C26H22N4O2HCl

Application Notes

• Application Notes: MU1700 is a potent (IC50s = 13 nM ALK1, 6 nM ALK2) and highly selective (selective against 369 kinases with only ALK6 (41 nM) being inhibited) ALK1/2 inhibitor. Much higher kinome selectivity than the typically used ALK 1/2 inhibitor LDN-193189. MU1700 exhibits favorable pharmacokinetic and bioavailability profiles for in vivo use. It showed excellent CNS penetration with brain concentrations exceeding that in plasma.