Palbociclib, CAS [[571190-30-2]]

Produktübersicht

• Artikelname: Palbociclib, CAS [[571190-30-2]]
• Artikelnummer: FBM-10-4760
• Hersteller Artikelnummer: 10-4760
• Alternativnummer: FBM-10-4760-5MG, FBM-10-4760-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-piperazin-1-yl)pyridine-2-yl]amino]-8H-pyrido[2,3-d]pyrimidin-7-one. Alternate Names: PD-332991, PD0332991

Produktbeschreibung

CDK4/CDK6 inhibitor

Produkteigenschaften

• Molekulargewicht: 447.53
• Reinheit: 99% by HPLC/TLC NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [571190-30-2]
• Formel: C24H29N7O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: Potent and selective inhibitor of Cdk4, IC50 = 11 nM and Cdk6, IC50 = 16 nM.1 Inhibits phosphorylation of Rb protein and cell cycle progression through G1 in primary 5T33MM cells and sensitized these cells to killing by a proteasome inhibitor (bortezomib) in mouse models.2 Induces autophagy and senescence in AGS gastric cancer cells.3 Clinically useful breast cancer agent.4 Cell cycle inhibitors boost tumor immunogenicity.5