Chemical Name: 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-piperazin-1-yl)pyridine-2-yl]amino]-8H-pyrido[2,3-d]pyrimidin-7-one. Alternate Names: PD-332991, PD0332991
CDK4/CDK6 inhibitor
Molecular Weight:
447.53
Purity:
99% by HPLC/TLC NMR (Conforms)
Form:
Yellow solid
CAS Number:
[571190-30-2]
Formula:
C24H29N7O2
Application Notes:
Potent and selective inhibitor of Cdk4, IC50 = 11 nM and Cdk6, IC50 = 16 nM.1 Inhibits phosphorylation of Rb protein and cell cycle progression through G1 in primary 5T33MM cells and sensitized these cells to killing by a proteasome inhibitor (bortezomib) in mouse models.2 Induces autophagy and senescence in AGS gastric cancer cells.3 Clinically useful breast cancer agent.4 Cell cycle inhibitors boost tumor immunogenicity.5
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