Crenolanib, CAS [[670220-88-9]]

Produktübersicht

• Artikelname: Crenolanib, CAS [[670220-88-9]]
• Artikelnummer: FBM-10-4782
• Hersteller Artikelnummer: 10-4782
• Alternativnummer: FBM-10-4782-5MG,FBM-10-4782-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: CP-868,596

Produktbeschreibung

PDGFR and FLT3 inhibitor

Produkteigenschaften

• Molekulargewicht: 443.55
• Reinheit: 97% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [670220-88-9]
• Formel: C26H29N5O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: Crenolanib is a potent inhibitor of PDGFR (Kd for alpha = 2.1 nM, ß = 3.2 nM) and FLT3 (Kd = 0.74 nM).1 Crenolanib is a type I inhibitor binding only to the active kinase conformation. It showed potent activity against imatinib-resistant PDGFRalpha mutations D842I, D842V, D842Y, DI842-843M, and deletion I8432 as well as FLT3/ITD and FLT3/D835 mutants3. Crenolanib acted synergistically with FLT3-CAR T-cells in a FLT3-ITD+ AML murine xenograft model.4