Crenolanib, CAS [[670220-88-9]]

Product Overview

• Article Name: Crenolanib, CAS [[670220-88-9]]
• Biozol Catalog Number: FBM-10-4782
• Supplier Catalog Number: 10-4782
• Alternative Catalog Number: FBM-10-4782-5MG, FBM-10-4782-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 1-[2-[5-[(3-Methyloxetan-3-yl)methoxy]benzimidazole-1-yl]quinoline-8-yl]piperidin-4-amine. Alternate Names: CP-868,596

Product Description

PDGFR and FLT3 inhibitor

Product Properties

• Molecular Weight: 443.55
• Purity: 97% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [670220-88-9]
• Formula: C26H29N5O2

Application Notes

• Application Notes: Crenolanib is a potent inhibitor of PDGFR (Kd for alpha = 2.1 nM, ß = 3.2 nM) and FLT3 (Kd = 0.74 nM).1 Crenolanib is a type I inhibitor binding only to the active kinase conformation. It showed potent activity against imatinib-resistant PDGFRalpha mutations D842I, D842V, D842Y, DI842-843M, and deletion I8432 as well as FLT3/ITD and FLT3/D835 mutants3. Crenolanib acted synergistically with FLT3-CAR T-cells in a FLT3-ITD+ AML murine xenograft model.4