TGX-221, CAS [[663619-89-4]]

Produktübersicht

• Artikelname: TGX-221, CAS [[663619-89-4]]
• Artikelnummer: FBM-10-4783
• Hersteller Artikelnummer: 10-4783
• Alternativnummer: FBM-10-4783-5MG, FBM-10-4783-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 9-(1-Anilinoethyl)-7-methyl-2-morpholino-4-ylpyrido[1,2-a]pyrimidin-4-one. Alternate Names: 7-Methyl-2-morpholino-9-(1-(phenylamino)ethyl)-4H-pyrido[1,2-a]pyrimidin-4-one

Produktbeschreibung

Potent and selective PI3Kß inhibitor

Produkteigenschaften

• Molekulargewicht: 364.45
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [663619-89-4]
• Formel: C21H24N4O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: TGX-221 is a potent (IC50 = 5 nM) and selective (1000-fold over p110alpha and p110gamma) inhibitor of PI3-kinase isoform p110ß.1 Displays anti-thrombotic activity without affecting bleeding time.1,2 It significantly inhibited tumorigenesis in VHL, SETD2, PTEN, and CDKN2A mutated clear cell renal cell carcinoma.3 TGX-221 induced apoptosis in glioblastoma cells and inhibited cell migration and invasion.4