TGX-221, CAS [[663619-89-4]]

Product Overview

• Article Name: TGX-221, CAS [[663619-89-4]]
• Biozol Catalog Number: FBM-10-4783
• Supplier Catalog Number: 10-4783
• Alternative Catalog Number: FBM-10-4783-5MG, FBM-10-4783-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 9-(1-Anilinoethyl)-7-methyl-2-morpholino-4-ylpyrido[1,2-a]pyrimidin-4-one. Alternate Names: 7-Methyl-2-morpholino-9-(1-(phenylamino)ethyl)-4H-pyrido[1,2-a]pyrimidin-4-one

Product Description

Potent and selective PI3Kß inhibitor

Product Properties

• Molecular Weight: 364.45
• Purity: 98% by HPLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [663619-89-4]
• Formula: C21H24N4O2

Application Notes

• Application Notes: TGX-221 is a potent (IC50 = 5 nM) and selective (1000-fold over p110alpha and p110gamma) inhibitor of PI3-kinase isoform p110ß.1 Displays anti-thrombotic activity without affecting bleeding time.1,2 It significantly inhibited tumorigenesis in VHL, SETD2, PTEN, and CDKN2A mutated clear cell renal cell carcinoma.3 TGX-221 induced apoptosis in glioblastoma cells and inhibited cell migration and invasion.4