MK-2206, CAS [[1032350-13-2]]

Produktübersicht

• Artikelname: MK-2206, CAS [[1032350-13-2]]
• Artikelnummer: FBM-10-4801
• Hersteller Artikelnummer: 10-4801
• Alternativnummer: FBM-10-4801-5MG, FBM-10-4801-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 8-(4-(1-Aminocyclobutyl)phenyl-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one dihydrochloride

Produktbeschreibung

Potent and selective AKT inhibitor

Produkteigenschaften

• Molekulargewicht: 480.39
• Reinheit: 98% by HPLC, NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [1032350-13-2]
• Formel: C25H21N5O2HCl

Anwendungsbeschreibung

• Anwendungsbeschreibung: MK-2206 is a potent and selective allosteric inhibitor of Akt (IC50s: Akt1 = 5 nM, Akt2 = 12 nM, Akt3 = 65 nM) that enhances the in vitro and in vivo antitumor efficacy of several standard chemotherapeutic agents.1 It was able to decrease insulin-stimulated glucose uptake, glycogen synthesis and glycogen synthase activity in rat muscle.2 MK-2206 induced G1-phase cycle arrest and sensitized HepG2 hepatocellular carcinoma cells to TRAIL-induced apoptosis.3