Chemical Name: 8-(4-(1-Aminocyclobutyl)phenyl-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one dihydrochloride
Potent and selective AKT inhibitor
Molecular Weight:
480.39
Purity:
98% by HPLC, NMR (Conforms)
Form:
Yellow solid
CAS Number:
[1032350-13-2]
Formula:
C25H21N5O2HCl
Application Notes:
MK-2206 is a potent and selective allosteric inhibitor of Akt (IC50s: Akt1 = 5 nM, Akt2 = 12 nM, Akt3 = 65 nM) that enhances the in vitro and in vivo antitumor efficacy of several standard chemotherapeutic agents.1 It was able to decrease insulin-stimulated glucose uptake, glycogen synthesis and glycogen synthase activity in rat muscle.2 MK-2206 induced G1-phase cycle arrest and sensitized HepG2 hepatocellular carcinoma cells to TRAIL-induced apoptosis.3
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