NU7441, CAS [[503468-95-9]]

Produktübersicht

• Artikelname: NU7441, CAS [[503468-95-9]]
• Artikelnummer: FBM-10-4810
• Hersteller Artikelnummer: 10-4810
• Alternativnummer: FBM-10-4810-5MG,FBM-10-4810-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Ku-57788

Produktbeschreibung

DNA-PK inhibitor

Produkteigenschaften

• Molekulargewicht: 413.49
• Reinheit: 98% by TLC NMR (Conforms)
• Formulierung: Off-white to beige solid
• CAS Nummer: [503468-95-9]
• Formel: C25H19NO3S

Anwendungsbeschreibung

• Anwendungsbeschreibung: NU7441 is a potent (IC50 = 13 nM) and selective ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK).1,2 It increased the toxicity of ionizing radiation and etoposide on SW620 human colon cancer lines via impeding DNA double-strand break repair.3 NU7441 also increased the radio/chemosensitivity of various other cancer cell lines.3-6 Reduces the frequency of NHEJ repair while enhancing the rate of HDR repair following CRISPR/Cas9-mediated gene editing.7