NU7441, CAS [[503468-95-9]]

Product Overview

• Article Name: NU7441, CAS [[503468-95-9]]
• Biozol Catalog Number: FBM-10-4810
• Supplier Catalog Number: 10-4810
• Alternative Catalog Number: FBM-10-4810-5MG, FBM-10-4810-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 8-Dibenzothiophen-4-yl-2-morpholin-4-ylchromen-4-one. Alternate Names: Ku-57788

Product Description

DNA-PK inhibitor

Product Properties

• Molecular Weight: 413.49
• Purity: 98% by TLC NMR (Conforms)
• Form: Off-white to beige solid
• CAS Number: [503468-95-9]
• Formula: C25H19NO3S

Application Notes

• Application Notes: NU7441 is a potent (IC50 = 13 nM) and selective ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK).1,2 It increased the toxicity of ionizing radiation and etoposide on SW620 human colon cancer lines via impeding DNA double-strand break repair.3 NU7441 also increased the radio/chemosensitivity of various other cancer cell lines.3-6 Reduces the frequency of NHEJ repair while enhancing the rate of HDR repair following CRISPR/Cas9-mediated gene editing.7