Quizartinib, CAS [[950769-58-1]]

Produktübersicht

• Artikelname: Quizartinib, CAS [[950769-58-1]]
• Artikelnummer: FBM-10-4813
• Hersteller Artikelnummer: 10-4813
• Alternativnummer: FBM-10-4813-5MG, FBM-10-4813-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 1-(5-(t-Butyl)isoxazol-3-yl)-3-(4-(7-(2-morpholinoethoxy)benzo[d]imidazo[2,1-b]thiazol-2-yl)phenyl)urea. Alternate Names: AC220

Produktbeschreibung

FLT3 inhibitor

Produkteigenschaften

• Molekulargewicht: 560.67
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: Off-whtie solid
• CAS Nummer: [950769-58-1]
• Formel: C29H32N6O4S

Anwendungsbeschreibung

• Anwendungsbeschreibung: Quizartinib is a potent and selective inhibitor of FLT3 (Kd = 1.6nM, IC50 = 0.56 nM MV4-11 cells).1 It is in clinical trials for treatment of Acute Myelogenous Leukemia (AML).2,3 Quizartinib priming resulted in prevention of myelosuppression in mice treated with 5-FU and Gemcitabine.4 Quizartinib showed significant reversal of ABCG2-mediated multidrug resistance ( 3 µM) via antagonism of drug efflux function.5,6