Quizartinib, CAS [[950769-58-1]]

Product Overview

• Article Name: Quizartinib, CAS [[950769-58-1]]
• Biozol Catalog Number: FBM-10-4813
• Supplier Catalog Number: 10-4813
• Alternative Catalog Number: FBM-10-4813-5MG, FBM-10-4813-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 1-(5-(t-Butyl)isoxazol-3-yl)-3-(4-(7-(2-morpholinoethoxy)benzo[d]imidazo[2,1-b]thiazol-2-yl)phenyl)urea. Alternate Names: AC220

Product Description

FLT3 inhibitor

Product Properties

• Molecular Weight: 560.67
• Purity: 98% by HPLC NMR (Conforms)
• Form: Off-whtie solid
• CAS Number: [950769-58-1]
• Formula: C29H32N6O4S

Application Notes

• Application Notes: Quizartinib is a potent and selective inhibitor of FLT3 (Kd = 1.6nM, IC50 = 0.56 nM MV4-11 cells).1 It is in clinical trials for treatment of Acute Myelogenous Leukemia (AML).2,3 Quizartinib priming resulted in prevention of myelosuppression in mice treated with 5-FU and Gemcitabine.4 Quizartinib showed significant reversal of ABCG2-mediated multidrug resistance ( 3 µM) via antagonism of drug efflux function.5,6